Jay and Silent Bob Strike Back is a tale of adventure on the open road. When Dante and Randal (of Clerks fame) get a restraining order to keep the punchy Jay and his hetero life-mate, Silent Bob, from selling drugs in front of the Quick Stop convenience store, their lives are suddenly empty. They find new purpose when their friend, Brodie, informs them a movie is being made featuring two infamous characters based on their likenesses. After visiting one of the creators of the Bluntman and...

An abortion clinic worker with a special heritage is enlisted to prevent two angels from reentering Heaven and thus undoing the fabric of the universe. Along the way, she is aided by two prophets, Jay and Silent Bob. With the help of Rufus, the 13th Apostle, they must stop those who stand in their way and prevent the angels from entering Heaven.